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Hear 1.3 serial key5/30/2023 We pay particular attention to factors affecting the spatial arrangement of Ca V channels at presynaptic, ribbon-type active zones, because the spatial relationship between Ca V channels and release sites has been shown to affect synapse function critically in a number of systems. Specifically, we describe molecular, biochemical, and biophysical properties of the Ca V channels in sensory receptor cells of the retina, cochlea, and vestibular apparatus, and we consider how such properties might change over the course of development and contribute to synaptic plasticity. This review concerns Ca V channels at ribbon synapses in primary sense organs and their specialization for efficient coding of stimuli in the physical environment. Calcium influx through voltage-gated Ca (Ca V) channels is the first step in synaptic transmission.
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